Last edited by Juran
Monday, May 11, 2020 | History

7 edition of RNA interference technology found in the catalog.

RNA interference technology

from basic science to drug development

  • 203 Want to read
  • 7 Currently reading

Published by Cambridge University Press in Cambridge, UK, New York .
Written in English

    Subjects:
  • Small interfering RNA,
  • Gene silencing

  • Edition Notes

    Includes bibliographical references and index.

    Statementedited by Krisharao Appasani ; forewords by Andrew Fire and Marshall Nirenberg.
    ContributionsAppasani, Krishnarao, 1959-
    Classifications
    LC ClassificationsQP623.5.S63 R63 2005
    The Physical Object
    Paginationxxxiii, 510 p., [16] p. of plates :
    Number of Pages510
    ID Numbers
    Open LibraryOL21187478M
    ISBN 100521836778
    LC Control Number2004054562
    OCLC/WorldCa55962410

      RNA interference (RNAi) is a mechanism that inhibits gene expression at the stage of translation or by hindering the transcription of specific genes. RNAi targ Slideshare uses cookies to improve functionality and performance, and to provide you with relevant advertising.   RNA Interference (RNAi) technology has rapidly become one of the key methods used in functional genomics. RNAi is used to block the expression of genes and create phenotypes that can potentially yield clues about the function of these genes/5(4).

      + RNA imaging in vivo + Modeling and prediction of RNA structure + RNA microarrays + Aptamer libraries and SELEX technology + RNA interference In short, a guide to successful experimentation for molecular biologists, biochemists and biotechnologists and of interest to every researcher experimenting with RNA. RNA Interference from Biology to Therapeutics. Editors this new technology but the fact remains that delivery is a key determinant in realizing the full clinical potential of RNA interference. There is an urgent need for better delivery methods to take this technology forward. This book addresses the role of different RNAi molecules in.

    This book reviews the selective and robust effect of RNAi on gene expression which makes it a valuable research tool, both in cell culture and in living organisms because synthetic dsRNA introduced into cells can induce suppression of specific genes of interest. This book will introduce new technology in the study of RNA interference in. I. RNA Interference uction In this chapter, we provide a brief overview of the RNA interference (RNAi) process and discuss technologies and products that can be used for RNAi experiments. A protocol is provided for the enzymatic synthesis of double-stranded RNA in vitro that provides an inexpensive alternative to chemical synthesis of RNAs.


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RNA interference technology Download PDF EPUB FB2

RNA interference (RNAi), an evolutionarily conserved mechanism triggered by double-stranded RNA (dsRNA), causes gene silencing in a sequence-specific manner. RNAi evolved naturally to mediate protection from both endogenous and exogenous pathogenic nucleic acids and to modulate gene expression.

Multiple technological advancements and precision in gene targeting have allowed a Author: Devi Singh, Sarika Chaudhary, Rajendra Kumar, Kamiya Mehla Preeti Sirohi, Anil Sirohi, Shashi Kumar.

RNA interference (RNAi), a hallmark of all biological sciences of twenty-first century, is an evolutionarily conserved and double-stranded RNA-dependent eukaryotic cell defense process. Opportunity to utilize an organisms own gene and to systematically induce and trigger RNAi for any desired sequence made RNAi an efficient approach for functional genomics, providing a solution for conventional.

RNA Interference (RNAi) technology has rapidly become one of the key methods used in functional genomics. In this overview, the basic concepts of RNAi biology are discussed, as well as the current and potential applications, providing an invaluable reference for all those who need to understand this emerging technology.

RNA interference RNA interference (RNAi) is a genetic regulatory system that functions to silence the activity of specific genes. RNAi occurs naturally, through the production of nuclear-encoded pre-microRNA (pre-miRNA), and can be induced experimentally, using short segments of synthetic double-stranded RNA (dsRNA).

Find many great new & used options and get the best deals for RNA Interference Technology: From Basic Science to Drug Development (, Hardcover) at the best online prices at eBay.

Free shipping for many products. RNA Interference (RNAi): The Nuts & RNA interference technology book of siRNA Technology (Nuts & Bolts Series) This book offers protocols and advise for the use of RNA Interference for knowking down expression of target genes in a number of different eukaryotes.

Varied applications in mammalian systems are explored in depth by authors currently working at the leading. Unlike journal articles, Gene Silencing by RNA Interference: Technology and Application combines essential background to the RNAi field with practical techniques designed by renowned researchers to provide the most diverse and in-depth examination of the subject yet.

This book describes methods and protocols for gene silencing and RNA : $ RNA Interference Technology: From Basic Science to Drug Development is primarily intended for readers in the molecular cell biology and genomics fields but may be useful in more advanced graduate level courses.

Much of the text should be of interest to those in applied sciences such as molecular medicine, genome science, and : $ Unlike journal articles, Gene Silencing by RNA Interference: Technology and Application combines essential background to the RNAi field with practical techniques designed by renowned researchers to provide the most diverse and in-depth examination of the subject yet.

This book describes methods and protocols for gene silencing and RNA interference. Introducing new technology in the study of RNA interference in microorganisms, plants, and animals, this book reviews the selective and robust effect of RNAi on gene expression.

This process is essential both in cell culture and in living organisms because synthetic dsRNA introduced into cells can induce suppression of specific genes of interest. Cambridge Core - Genomics, Bioinformatics and Systems Biology - RNA Interference Technology - edited by Krishnarao AppasaniAuthor: Andrew Fire, Marshall Nirenberg.

ISBN: OCLC Number: Description: viii, pages: illustrations ; 22 cm. Contents: Section I. RNA interference as an experimental.

"The use of RNA interference to control gene expression is emerging as an exciting new technology. The potential of this mechanism depends on the ability to find a competent way to deliver the RNA.

This compact book reviews all of these issues in a comprehensive manner." from Doodys (). RNA interference (RNAi) is a relatively new technology that is revolutionizing the way that researchers study mammalian gene expression.

RNAi has had significant impact on the ease, speed, and specificity with which the loss of gene function analysi. An ancient antiviral mechanism. Over the next few years the mechanism underlying RNA interference was established from work on diverse organisms, especially the worm and the fruit fly.

4 RNA interference was considered to be an evolutionarily ancient mechanism for protecting organisms from viruses. Many viruses have RNA, rather than DNA, as their genetic material and go through at Cited by: Robert E. Farrell Jr. Ph.D, in RNA Methodologies (Fourth Edition), Publisher Summary.

RNA interference (RNAi) is a naturally occurring mechanism for gene silencing induced by the presence of short interfering RNA (siRNA). RNAi is an endogenous catalytic pathway that is triggered by double-stranded RNA (dsRNA). The trigger can occur naturally, as in the case of a cellular infection by a.

Erratum: EGO-1 is related to RNA-directed RNA polymerase and functions in germ-line development and RNA interference in C. elegans (Current Biology () 10 ()) Article May RNA Interference (RNAi) Introduction.

RNA interference or Post-Transcriptional Gene Silencing is a conserved biological response to double-stranded RNA that mediates resistance to both endogenous parasitic and exogenous pathogenic nucleic acids, and regulates the expression of protein-coding natural mechanism for sequence-specific gene silencing promises to revolutionize.

About this book. RNA Interference (RNAi) technology has rapidly become one of the key methods used in functional genomics. RNAi is used to block the expression of genes and create phenotypes that can potentially yield clues about the function of these Range: £ - £ The book RNA interference, a collection of 19 chapters from distinguished laboratories and eminent sci‐ entists of the world conducting state-of-the-art RNAi research, aims to provide readers.

Gene therapy in mice builds muscle, reduces fat – Washington University School of Medicine in St. Louis. Washington University School of Medicine in St. Louis - 3 days ago.This book collects techniques for the use of RNA interference (RNAi) to develop bio-drugs forcancer research, focusing on nanoparticle-based targeted deliveries, including aptamers, as well as techniques for using RNAi technology to combat various cancers in preclinical studies." RNA interference holds a huge amount of promise for a number of disorders, one of which is cancer, but also neurological disorders and immune disorders," she says.

RNA Interference Cancer Treatment "Our challenge with RNA interference technology is to figure out how to deliver it into the human brain in a sustained, safe and effective manner.